Do you want to increase your growth hormone levels, then you should consider MK-677 (Ibutamoren).
If you have already spent some time on our website, you should definitely be familiar with SARMs.
Selective Androgen Receptor Modulators are similar to conventional steroids in their effect.
However, they bring the desired results with less side effects.
What is MK-677 (Ibutamoren)
Before we go deeper into the matter, we have to ask ourselves what MK-677 or Ibutamoren actually is.
Because technically this substance, which is also known as Nutrabol, is not a SARM in the traditional sense.
In fact, the drug does not bind to the body’s androgen receptors, nor does it mimic the effects of steroids.
The substance actually belongs to a group of peptides that ensure that the body produces more growth hormones (HGH).
Ibutamoren is a substance that has been the subject of more discussions in online forums than actual clinical trials.
However, the study so far supports several benefits of Ibutamoren related to its ability to increase growth hormone and IGF-1 levels.
Ibutamoren may increase growth hormone, IGF-1 and IGFBP-3 levels in children with growth hormone deficiency.
In addition, these effects are achieved without altering the concentrations of prolactin, glucose, triiodothyronine (T3), (T4), thyrotropin, cortisol or insulin.
In men and women with severe GH deficiency, ibutamoren increases IGF-1 and growth hormone without significant changes in cortisol, PRL and thyroid hormone levels. However, insulin and glucose increase.
MK-677 was first mentioned in studies almost 30 years ago. Ibutamoren was given to dogs both orally and intravenously. This led to a sustained increase in growth hormone and IGF-1 release.
The substance is developed and produced in Darmstadt, where the pharmaceutical company Merck KGaA holds the patent.
How Does MK-677 Work
Ibutamoren binds to the ghrelin receptors on cell surfaces inside the body, triggering several chain reactions.
Among other things, more growth hormones (human growth hormone) and IGF-1 (insulin-like growth factor) are released during this process.
In doing so, it mimics the effect of ghrelin on the cell. Ghrelin is a peptide hormone released by endocrine cells in the gut and stomach.
Ibutamoren increases growth hormone levels by mimicking the action of the hormone Ghrelin and binding to one of the Ghrelin receptors (GHSR) in the brain.
Activated GHSR stimulates the release of growth hormone from the brain.
GHSR is found in areas of the brain that control appetite, pleasure, mood, biological rhythms, memory and cognition. Therefore, we can expect that Ibutamoren may also affect these functions.
For example, it controls the structure of adipose tissue and also controls the functioning of energy metabolism, resulting in improvements in athletic performance.
The most sought after property of MK-677 is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol.
Cortisol suppresses the immune system, reduces wound healing, impairs memory, and the presence of high levels of cortisol is usually not desirable.
By mimicking the effects of ghrelin, MK-677 offers the following benefits:
- Increased muscle building
- Reduced muscle loss
- Increased bone density
- Improved sleep quality
- Rapid cell regeneration
- Accelerated fat loss
These all benefits come from an increased release of Human Growth Hormone (growth hormone) and IGF-1.
The recommended dose per day is around 15-25 mg. However, if you are currently in the process of muscle building, a combination with at least one of the other SARMs products could be beneficial. You can use it together with Cardarine, for example.
Insulin, anabolic steroids or various SARMs could be a useful addition. Since it is important to eat a lot during a phase of muscle building, Ibutamoren is a good choice as it stimulates the appetite.
For women, the MK-677 dosage is similar: 5 to 25 mg per day. However, you should decide which dose is good for your body and causes the desired build-up of muscle mass.
Women should not worry about possible masculinization, since Ibutamoren MK-677 has no side effects pointing in that direction.
For optimal stimulation of the production of Human Growth Hormone (growth hormone) and IGF-1, however, you should not let the dosage exceed 25 mg per day.
It is also important that you have patience because growth hormones and IGF-1 need time to increase inside your body.
MK-677 Cycle Length
For this reason, MK-677 cycle should generally be between 12 and 14 weeks to have the best effect on the body’s levels of growth hormone (growth hormone).
It would be also beneficial if you use RAD-140 alongside MK-677 to increase your testosterone.
MK-677 Detection Time
Unfortunately, the current studies does not yet offer an outlook on the half-life in the body. So, it is really hard to tell how long Ibutamoren or its metabolic products will stay in the system.
MK-677 Side Effects
The most common side effects of Ibutamoren are increased appetite and transient, mild swelling in the lower extremities (water retention) and muscle pain.
Several studies have shown an increase in fasting blood glucose and a decrease in insulin sensitivity.
These side effects are similar to those seen in people with increased levels of growth hormone, mainly joint pain and insulin resistance.
Although most studies showed few or no side effects, one study was stopped due to serious side effects.
Elderly patients with hip fractures have experienced increased blood pressure, blood sugar and HbA1c, and there have been cases of congestive heart failure.
Also, in theory, increased production of growth hormone (HGH) and IGF-1 means that the body can produce cancer cells in extreme cases.
Men in particular are affected by this risk, as these two substances are said to be linked to prostate cancer.
Is MK-677 Legal
Just like with SARMs, we are legally in a gray area. So it is forbidden to sell the substance for human use. But owning a small amount for personal use is currently permitted.
Where to buy MK-677 (Ibutamoren)
With SARMs and steroids, before you buy the product, you should make sure that you are only ordering from reputable dealers.
Since we are legally in a gray area, shabby dealers often try to contaminate products with other “cheaper” substances and thus rob the product of its effect.
However, if you want to be on the safe side when buying ibutamoren, you should seek out reputable SARMs alternative retailers like these (there are very few of them unfortunately!).
There you can be sure that everything is correct and that you are only purchasing the purest Ibutamoren products.
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Ibutamoren is a SARM that can be leveled with injectable growth hormone. The difference is that MK677 will stimulate the pituitary gland to produce more growth hormone, and the synthetic version is injected by adding artificial growth hormone, and in large doses, the body would stop producing natural GH.
Ibutamoren is often used as an anabolic substance to increase lean muscle mass. It is orally active and can be taken once a day.
As mentioned earlier, ibutamoren increases growth hormone and IGF-1 levels. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength and reduce body fat.
In healthy obese men, two months of Nutrobal treatment increased lean mass and transiently increased basal metabolic rate (BMR).
So, if you want to boost your progress in building muscle mass and increasing your strength, Ibutamoren MK-677 is definitely a good option for you.
Even if other SARMs are sometimes stronger than this one, the race is definitely decided by the side effects.
For the majority of the men and women, these are mostly manageable.